AMP-activated protein kinase (AMPK) regulates cellular energy metabolism by phosphorylation of key enzymes in metabolic pathways, such as acetyl–coenzyme A carboxylase (ACC) (1) or mTOR (mammalian target of rapamycin) (2), by modulating their activities, and by regulating the activity of transcription factors (3) and transcriptional cofactors (4).
