Herpes Simplex Virus types 1 and 2 produce infections which are expressed in a variety of clinical manifestations ranging from mild stomatitis to disseminated and fatal disease. The more common clinical manifestations include gingivostomatitis, keratitis, conjunctivitis, vesicular skin eruptions, aseptic meningitis, neonatal herpes, encephalitis, genital tract infections, and disseminated primary infection.