p53 in Cancer Pathway 

p53 is an important factor in tumor suppression and is activated in response to cellular stress to induce cell cycle arrest or apoptosis. p53 mutants found in tumors are no longer functional as tumor suppressors, resulting in cell malignancies. The immune response in tumor patients correlates with the presence of p53 mutations, leading to the accumulation of ineffective p53 proteins in the tumor cells.

 

p53_Pathway